Anti-DDX18 monoclonal antibody (DCABH-11243) Made to order

Rabbit anti-Human DDX18 monoclonal antibody for WB, ELISA

View other DDX18 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DDX18 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DDX18; DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 18 (Myc regulated); ATP-dependent RNA helicase DDX18; MrDb; DEAD box protein 18
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DDX18 (DEAD-Box Helicase 18) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein.
Antigen Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. Probable RNA-dependent helicase. The function about DDX18 antigen include ATP binding; ATP-dependent RNA helicase activity; RNA binding; helicase activity; hydrolase activity; nucleotide binding; protein binding.
Pathway
Validated targets of C-MYC transcriptional activation, organism-specific biosystem.

Citations


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References


Hammoudi, A; Song, F; et al. Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 440:364-370(2013).
Miyado, M; Nakamura, M; et al. Mamld1 Deficiency Significantly Reduces mRNA Expression Levels of Multiple Genes Expressed in Mouse Fetal Leydig Cells but Permits Normal Genital and Reproductive Development. ENDOCRINOLOGY 153:6033-6040(2012).

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