Anti-DBF4B monoclonal antibody (DCABH-11222) Made to order

Rabbit anti-Human DBF4B monoclonal antibody for WB, ELISA

View other DBF4B antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DBF4B is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DBF4B; DBF4 homolog B (S. cerevisiae); protein DBF4 homolog B; ASKL1; chifb; chiffon homolog B (Drosophila)
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DBF4B (DBF4 Zinc Finger B) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication. GO annotations related to this gene include nucleic acid binding and protein kinase activator activity. An important paralog of this gene is DBF4. This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants.
Antigen Description
This gene encodes a regulator of the CDC7-like 1 protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and its expression is cell cycle-regulated. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full length sequences have not been determined. Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at Ser-40 and then is involved in regulating the initiation of DNA replication during cell cycle. The function about DBF4B antigen include metal ion binding; nucleic acid binding; zinc ion binding.

Citations


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References


Guo, BQ; Lee, HY; et al. Cloning and characterization of Chinese hamster homologue of yeast DBF4 (ChDBF4). GENE 264:249-256(2001).
Hess, GF; Drong, RF; et al. A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. GENE 211:133-140(1998).

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