Anti-DAG1 monoclonal antibody, clone 3349

Antibody Isotype

IgG2b, κ

Clone

3349

Species Reactivity

Mouse; Rat; Human; Bovine; Rabbit

Immunogen

Other Immunogen Type corresponding to Cow Alpha Dystroglycan.

Conjugate

Application Notes

Recommended concentration:
WB: 1/100 - 1/1000

Alternative Names

DAG1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystroglycan; RAB7, member RAS oncogene family; dystrophin-associated glycoprotein 1; RAB7;

Entrez Gene ID

UniProt ID

Antigen Description

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.

Pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem;