Magic™ Anti-Cytokeratin monoclonal antibody, clone Lt20. 3

Adamantinoma is a low-grade malignant bone tumor with metastatic potential in the range of 15-20%, commonly affecting mid-diaphyseal tibial region and jaw. Numerous cases of adamantinoma affecting the appendicular skeleton have been reported but only three in the pelvis till date. We present the case of a 24-year-old male, who was initially reported as fibrous dysplasia for a lesion in pelvis. On review, a cellular tumor was noted, including areas resembling fibrous dysplasia, along with cords and nests of polygonal cells, which displayed positive immunoexpression with cytokeratin and p40. Subsequently, he underwent wide local resection (internal hemipelvectomy), along with mesh pseudoarthrosis was done. Diagnosis of adamantinoma was further confirmed, with clear resection margins. Currently, the patient is on a regular clinical and radiological follow-up. Careful assessment of key histomorphologic features, coupled with immunohistochemical stains and clinico-radiological correlation, is helpful in identifying this uncommon tumor at a rather rare site.

Ganglion cell-containing pituitary adenomas that are neurofilament protein-positive are the exceedingly rare form of pituitary ganliocytomas. We report a case of a 23-year-old male patient who presented with a clinical picture of acromegaly in addition to raised prolactin level. Histopathology showed areas exhibiting pseudopapillary and solid proliferation of round and monotonous blue cells. The immunohistochemistry showed strong reactivity for synaptophysin and growth hormone and focal reactivity to prolactin. Fibrous bodies are confirmed using cytokeratin immunostain, in keeping with sparsely granulated somatotroph component. The patient remained free of recurrence after one year of radiological follow-up.