CRTAM extracellular region-human IgG Fc fusion protein
Conjugate
APC
Target
Alternative Names
Crtam; cytotoxic and regulatory T cell molecule; Class I-restricted T cell-associated molecule; cytotoxic and regulatory T-cell molecule; class I-restricted T cell-associated molecule; class-I MHC-restricted T-cell-associated molecule
Class-I MHC-restricted T-cell associated molecule (CRTAM), designated as CD355, is an Ig domain like type I transmembrane receptor, which belongs to the nectin family. In the immune system, CRTAM is strictly expressed on activated NK cells and activated CD8-positive T cells. By binding its ligand Nectin-like molecule 2 (Necl2), CRTAM plays an important role in mediating cell adhesion and migration.
Pathway
Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem
Citations
Publication ()
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