Specifications
Species Reactivity
Human, Mouse
Immunogen
CRTAM extracellular region-human IgG Fc fusion protein
Target
Alternative Names
Crtam; cytotoxic and regulatory T cell molecule; Class I-restricted T cell-associated molecule; cytotoxic and regulatory T-cell molecule; class I-restricted T cell-associated molecule; class-I MHC-restricted T-cell-associated molecule
Product Background
Antigen Description
Class-I MHC-restricted T-cell associated molecule (CRTAM), designated as CD355, is an Ig domain like type I transmembrane receptor, which belongs to the nectin family. In the immune system, CRTAM is strictly expressed on activated NK cells and activated CD8-positive T cells. By binding its ligand Nectin-like molecule 2 (Necl2), CRTAM plays an important role in mediating cell adhesion and migration.
Pathway
Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem
Citations
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Steigerwald, J; Raum, T; et al. Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells. MABS 1:115-127(2009).
Garay, E; Patino-Lopez, G; et al. CRTAM: A Molecule Involved in Epithelial Cell Adhesion. JOURNAL OF CELLULAR BIOCHEMISTRY 111:111-122(2010).
COA
Certificate of Analysis