Anti-CRTAM monoclonal antibody (DMABT-H18449)

Rat anti-Human CRTAM monoclonal antibody for IF, FC Datasheet

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Specifications


Host Species
Rat
Antibody Isotype
IgG2a
Clone
3I6
Species Reactivity
Mouse
Immunogen
CRTAM extracellular region-human IgG Fc fusion protein
Conjugate
Unconjugated

Applications


Application Notes
For immunofluorescent staining, the suggested use of this reagent is ≤1.0 μg per million cells in 100 μl volume or 100 μl of whole blood.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CRTAM; cytotoxic and regulatory T cell molecule; cytotoxic and regulatory T-cell molecule; class I-restricted T cell-associated molecule; class-I MHC-restricted T-cell-associated molecule; MGC141606
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CRTAM (Cytotoxic And Regulatory T-Cell Molecule) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include receptor binding. An important paralog of this gene is CADM3. The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al. , 2008 [PubMed 18329370]).
Antigen Description
Class-I MHC-restricted T-cell associated molecule (CRTAM), designated as CD355, is an Ig domain like type I transmembrane receptor, which belongs to the nectin family. In the immune system, CRTAM is strictly expressed on activated NK cells and activated CInteraction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. The function about CRTAM antigen include protein binding; receptor binding; receptor binding; receptor binding.
Pathway
Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem.

Citations


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References


Steigerwald, J; Raum, T; et al. Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells. MABS 1:115-127(2009).
Galibert, L; Diemer, GS; et al. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. JOURNAL OF BIOLOGICAL CHEMISTRY 280:21955-21964(2005).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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