Specifications
Immunogen
RBL-2H3 cells stably expressing HA-tagged mouse CLEC2.
Applications
Application Notes
Flow Cyt: Neat - 1/10
Target
Alternative Names
Clec2g; C-type lectin domain family 2, member g; Clrc; Clrd; Clrx; Clr-c; Ddv10; Ocilrp1; 4632413B12Rik; C-type lectin domain family 2 member G; ocil-related protein 1; C-type lectin-related protein C; C-type lectin-related protein x variant 1; osteoclast
Product Background
Antigen Description
CLEC2 acts as a receptor for rhodocytin, a platelet-aggregating protein found in snake venom. CLEC2 expression is not restricted to platelets and also acts as an activation receptor on neutrophils.
Citations
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Dean, YD; McGreal, EP; et al. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. EUROPEAN JOURNAL OF IMMUNOLOGY 31:1370-1381(2001).
Wang, MY; Wang, FP; et al. Mannan-Binding Lectin Inhibits Candida albicans-Induced Cellular Responses in PMA-Activated THP-1 Cells through Toll-Like Receptor 2 and Toll-Like Receptor 4. PLOS ONE 8:-(2013).