Anti-POP1 monoclonal antibody (DMAB9517MC)

Mouse anti-Chicken POP1 monoclonal antibody for WB, IHC, AP Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3F11
Species Reactivity
Chicken
Immunogen
Pop1 from recombinant protein, chicken derived
Conjugate
Unconjugated

Target


Alternative Names
POP1; processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae); ribonucleases P/MRP protein subunit POP1; BVES; POPDC1
Entrez Gene ID

Product Background


Gene summary
POP1 (POP1 Homolog, Ribonuclease P/MRP Subunit) is a Protein Coding gene. Diseases associated with POP1 include anauxetic dysplasia. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include poly(A) RNA binding and ribonuclease MRP activity. This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants.
Antigen Description
Pop1 (BVES) is a member of the Popeye gene family which was named for its high-level expression in the heart and other muscle lineages. However, these proteins have no sequence similarity to any other gene family and their function is unclear. Here we report the production of recombinant chicken Pop1/BVES protein and the generation of two Pop1/BVES specific monoclonal antibodies (MAbs) 3F11-D9-E8 and 1B3-G11-A8. These antibodies detect recombinant Pop1/BVES in ELISAs and endogenous chicken Pop1/BVES in chicken heart extracts by Western blotting. Note=Defects in POP1 may be the cause of a severe skeletal dysplasia reminiscent of anauxetic dysplasia. Affected individuals show severe growth retardation of prenatal onset, a bone dysplasia affecting the epiphyses and metaphyses of the long bones particularly in the lower limbs, and abnormalities of the spine including irregularly shaped vertebral bodies and marked cervical spine instability. Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene. POP1 is a protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. This protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing.
Pathway
RNA transport; Ribosome biogenesis in eukaryotes.

Citations


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References


DiAngelo, JR; Vasavada, TK; et al. Production of monoclonal antibodies against chicken Pop1 (BVES). HYBRIDOMA AND HYBRIDOMICS 20:377-381(2001).
Vasavada, TK; DiAngelo, JR; et al. Developmental expression of Pop1/Bves. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 52:371-377(2004).

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