Anti-CYR61 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Cow; Human

Immunogen

Synthetic peptide corresponding to Mouse CCN1. Synthetic peptide surrounding amino acid 166 of mouse Cyr61. The peptide was 10-15 amino acids long.

Conjugate

Application Notes

ICC/IF: 1/50; IHC-P: 2 μg/ml; WB: 1 - 4 μg/ml;

Alternative Names

CYR61; cysteine rich protein 61; CCN1; Igfbp10; AI325051; protein CYR61; 3CH61; IBP-10; IGFBP-10; intermediate early; CCN family member 1; IGF-binding protein 10; cysteine-rich angiogenic inducer 61; insulin-like growth factor binding protein 10; insulin-

Entrez Gene ID

UniProt ID

Antigen Description

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Pathway

Hypertrophy Model; XPodNet - protein-protein interactions in the podocyte expanded by STRING;