Specifications
Immunogen
Synthetic peptide derived from C terminus of Human CYP24A1.
Target
Alternative Names
CYP24A1; cytochrome P450, family 24, subfamily A, polypeptide 1; CYP24, cytochrome P450, subfamily XXIV (vitamin D 24 hydroxylase); 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; CP24; P450 CC24; 24-OHase; cytochrome P450 24A1; cytochrome P450-
Product Background
Antigen Description
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
Pathway
Biological oxidations; Cytochrome P450 - arranged by substrate type; Metabolism; Metabolism of lipids and lipoproteins; Metabolism of steroid hormones and vitamins A and D; Nuclear receptors in lipid metabolism and toxicity; Phase 1 - Functionalization of
Citations
Publication ()
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COA
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