Specifications
Immunogen
CYP24A1 (NP_000773, 415 a.a. ~ 514 a.a) partial recombinant protein with GST tag. The sequence is LMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHL ALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
Target
Alternative Names
CYP24A1; cytochrome P450, family 24, subfamily A, polypeptide 1; CP24; HCAI; CYP24; P450-CC24; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; cytochrome P450 24A1; cytochrome P450-CC24; vitamin D 24-hydroxylase; exo-mitochondrial prot
Product Background
Antigen Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Pathway
Biological oxidations; Metabolism; Metabolism of steroid hormones and vitamin D; MicroRNAs in cancer
Citations
Publication ()
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COA
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