Specifications
Immunogen
A synthetic peptide of human CYP11B1 is used for rabbit immunization.
Target
Alternative Names
CYP11B1; cytochrome P450, family 11, subfamily B, polypeptide 1; CYP11B, cytochrome P450, subfamily XIB (steroid 11 beta hydroxylase), polypeptide 1; cytochrome P450 11B1, mitochondrial; CPN1; FHI; P450C11; CYPXIB1; cytochrome P450C11; cytochrome P-450c11
Product Background
Antigen Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
Pathway
Biological oxidations, organism-specific biosystem; C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone, organism-specific biosystem; corticosterone/aldosterone, conserved biosystem; cortisol/cortisone, organism-specific biosystem.
Citations
Publication ()
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COA
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