Anti-CXCL12 monoclonal antibody, clone 80029

Antibody Isotype

IgG1

Clone

80029

Species Reactivity

Human

Immunogen

E. coli-derived recombinant human CXCL12/SDF-1 alpha . Lys22-Lys89 Accession Number Q6ICW0

Conjugate

Application Notes

Flow Cyt: 2.5 μg/10⁶ cells;
Immunohistochemistry: 8-25 μg/mL;
Human CXCL12/SDF-1 beta Sandwich Immunoassay: ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL;

Alternative Names

CXCL12; chemokine (C-X-C motif) ligand 12; IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12; stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor;

Entrez Gene ID

UniProt ID

Antigen Description

CXCL12/Stromal Cell-derived Factor 1 (SDF-1) is a member of the CXC chemokine ligand superfamily. Six alternatively spliced CXCL12/SDF-1 isoforms have been identified including, CXCL12/SDF-1 alpha, CXCL12/SDF-1 beta, and CXCL12/SDF-1 gamma. CXCL12/SDF-1 alpha is 89 amino acids (aa) in length with a predicted molecular weight of 10 kDa, CXCL12/SDF-1 beta is 93 aa in length with a predicted molecular weight of 10.6 kDa, and CXCL12/SDF-1 gamma is 119 aa in length with a predicted molecular weight of 13.7 kDa. The mouse CXCL12/SDF-1 orthologs share 99% aa sequence identity with the human protein. The alpha and beta isoforms are ubiquitously expressed while the gamma isoform is primarily expressed in the heart. CXCL12/SDF-1 isoforms are chemotactic for T lymphocytes and monocytes. It is cardio protective and has also been shown to hinder CXCR4-mediated HIV infection of T cells.

Pathway

Axon guidance; CXCR4-mediated signaling events; Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; G alpha (i) signalling events; GPCR downstream signaling;