Specifications
Immunogen
Recombinant full length protein corresponding to Human delta 1 Catenin aa 1-968. Produced in HEK293T cells.Sequence: MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQD ANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIP RMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRR
Applications
Application Notes
WB: 1/2000; IHC-P: 1/150;
Target
Alternative Names
CTNND1; catenin (cadherin-associated protein), delta 1; CTNND; catenin delta-1; KIAA0384; p120; p120cas; p120ctn; p120 catenin; cadherin-associated Src substrate; CAS; P120CAS; P120CTN; p120(CAS); p120(CTN);
Product Background
Antigen Description
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Pathway
Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;
Citations
Publication ()
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COA
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