Specifications
Species Reactivity
Mouse; Rat; Chicken; Cow; Dog; Human
Immunogen
This antibody is derived from the 6H11 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an A/J mouse immunized with a recombinant N-terminal fragment of murine delta 1 Catenin.
Applications
Application Notes
WB: 1/10000;
Target
Alternative Names
CTNND1; catenin (cadherin associated protein), delta 1; catenin delta-1; CAS; p120(cas); p120(ctn); catenin src; p120 catenin; p120-catenin; cadherin-associated Src substrate; P120; Catns; Ctnnd; AA409437; AU019353; mKIAA0384;
Product Background
Antigen Description
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Pathway
Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem;
Citations
Publication ()
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COA
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