CSTF3 (AAH09792, 1 a.a. ~ 103 a.a) full-length recombinant protein with GST tag. The sequence is MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQ FPSSGRFWKLYIEAEVTILFYFFLYQYCSIHCSDRKQVRNIAN
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3 end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
Pathway
Cleavage of Growing Transcript in the Termination Region; Processing of Capped Intron-Containing Pre-mRNA; Processing of Intronless Pre-mRNAs; RNA Polymerase II Transcription Termination
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