Anti-CREB3 (aa 231-395) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 231-395 of Human CREB3 (Uniprot ID: O43889).

Conjugate

Application Notes

WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000.

Alternative Names

CREB3; cAMP responsive element binding protein 3; cAMP responsive element binding protein 3 (luman); cyclic AMP-responsive element-binding protein 3; Luman; LZIP; CREB-3; basic leucine zipper protein; transcription factor LZIP-alpha; cAMP-responsive eleme

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.

Pathway

Amphetamine addiction; Cholinergic synapse; Cocaine addiction; Dopaminergic synapse;