Anti-CREB3 monoclonal antibody (DMABT-H13504)

Mouse anti-Human CREB3 monoclonal antibody for WB, IHC, sELISA, ELISA, RNAi Knockdown Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4I6
Species Reactivity
Human
Immunogen
CREB3 (NP_006359, 273 a.a. ~ 371 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CREB3; cAMP responsive element binding protein 3; cAMP responsive element binding protein4(luman); cyclic AMP-responsive element-binding protein 3; Luman; LZIP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CREB3 (CAMP Responsive Element Binding Protein 3) is a Protein Coding gene. Diseases associated with CREB3 include herpes simplex and scarlet fever. Among its related pathways are cAMP signaling pathway and Insulin secretion. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is CREB3L3. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
Antigen Description
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. Its transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5-CCAC[GA]-3half of ERSE II (5-ATTGG-N-CCACG-3). Associates with chromatin to the HERPUD1 promoter. Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene. 0The function about CREB3 antigen include CCR1 chemokine receptor binding; DNA binding; cAMP response element binding protein binding; protein binding; protein dimerization activity; protein dimerization activity; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity.
Pathway
Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem.

Citations


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References


SAKAMOTO, KM; FRASER, JK; et al. GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND INTERLEUKIN-3 SIGNALING PATHWAYS CONVERGE ON THE CREB-BINDING SITE IN THE HUMAN EGR-1 PROMOTER. MOLECULAR AND CELLULAR BIOLOGY 14:5975-5985(1994).
Cheng, KW; Leung, PCK; et al. Human chorionic gonadotropin-activated cAMP pathway regulates human placental GnRH receptor gene transcription in choriocarcinoma JEG-3 cells. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 87:3291-3299(2002).

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