Anti-COPA (internal region) polyclonal antibody

Species Reactivity

Chicken; Human; Mouse; Pig; Rat

Immunogen

A synthetic peptide corresponding to internal region of human COPA. The sequence is CTRASNLENST

Conjugate

Application Notes

ELISA: 1:1000; WB: 0.5-2μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

COPA; coatomer protein complex, subunit alpha; HEP-COP; coatomer subunit alpha; xenin; HEPCOP; proxenin; alpha-COP; alpha coat protein; alpha-coat protein;

Entrez Gene ID

UniProt ID

Antigen Description

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.

Pathway

Arf1 pathway; COPI Mediated Transport; Membrane Trafficking;