Anti-COPA monoclonal antibody, clone FQS25384(C)

Antibody Isotype

IgG

Clone

FQS25384(C)

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human alpha COP I aa 1-100. The exact sequence is proprietary.Database link: P53621

Conjugate

Application Notes

WB: 1/10000 - 1/50000. Detects a band of approximately 150 kDa (predicted molecular weight: 138 kDa); IHC-P: 1/50 - 1/100.

Alternative Names

COPA; coatomer protein complex subunit alpha; coatomer subunit alpha; alpha-COP; alpha-coat protein; xenin; AU040324;

Entrez Gene ID

UniProt ID

Antigen Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.

Pathway

COPI Mediated Transport, organism-specific biosystem; Golgi to ER Retrograde Transport, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem.