Synthetic peptide conjugated to KLH, corresponding to a region within N-terminal amino acids 61-89 of Human Collagen VIII alpha 1 (NP_001841.2, NP_065084.2).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/100 - 1/500.
Target
Alternative Names
COL8A1; collagen, type VIII, alpha 1; C3orf7; collagen alpha-1(VIII) chain; endothelial collagen; collagen VIII, alpha-1 polypeptide; cell proliferation-inducing protein 41; smooth muscle cell-expressed and macrophage conditioned medium-induced protein sm
Macromolecular component of the subendothelium. Major component of the Descemets membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in artherogenesis.Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
Pathway
Assembly of collagen fibrils and other multimeric structures; Collagen formation;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Gottsch, JD; Zhang, C; et al. Fuchs corneal dystrophy: Aberrant collagen distribution in an L450W mutant of the COL8A2 gene. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46:4504-4511(2005).
Gerth, J; Cohen, CD; et al. Collagen type VIII expression in human diabetic nephropathy. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 37:767-773(2007).
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COA
Certificate of Analysis
