Anti-COL8A1 monoclonal antibody (DCABH-11085) Made to order

Rabbit anti-Human COL8A1 monoclonal antibody for WB, ELISA

View other COL8A1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human COL8A1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
COL8A1; collagen, type VIII, alpha 1; C3orf7, chromosome 3 open reading frame 7; collagen alpha-1(VIII) chain; MGC9568; endothelial collagen
Entrez Gene ID
UniProt ID

Product Background


Gene summary
COL8A1 (Collagen Type VIII Alpha 1) is a Protein Coding gene. Diseases associated with COL8A1 include fuchs endothelial dystrophy and macular degeneration, age-related, 1. Among its related pathways are Degradation of the extracellular matrix and ERK Signaling. An important paralog of this gene is ADIPOQ. This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed.
Antigen Description
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same isoform have been observed. Macromolecular component of the subendothelium. Major component of the Descemets membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene.

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References


Gottsch, JD; Zhang, C; et al. Fuchs corneal dystrophy: Aberrant collagen distribution in an L450W mutant of the COL8A2 gene. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46:4504-4511(2005).
Gerth, J; Cohen, CD; et al. Collagen type VIII expression in human diabetic nephropathy. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 37:767-773(2007).

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