Specifications
Species Reactivity
Mouse; Human
Immunogen
Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 33-63 of Human Collagen IV alpha 1.
Applications
Application Notes
WB: 1/50 - 1/100;
Target
Alternative Names
COL4A1; collagen, type IV, alpha 1; ICH; HANAC; POREN1; arresten; collagen alpha-1(IV) chain; COL4A1 NC1 domain; collagen IV, alpha-1 polypeptide; collagen of basement membrane, alpha-1 chain;
Product Background
Antigen Description
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.
Pathway
Amoebiasis; Assembly of collagen fibrils and other multimeric structures; Binding and Uptake of Ligands by Scavenger Receptors; Collagen formation
Citations
Publication ()
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COA
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