Anti-COL4A1 monoclonal antibody, clone 2154

Antibody Isotype

IgG1

Clone

2154

Species Reactivity

Cow; Human; Pig

Immunogen

Full length native protein, purified from Human placenta

Conjugate

Application Notes

WB: 1/100 - 1/1000; IHC-P: 1/50 - 1/100; IHC-Fr: 1/50 - 1/100; ICC: 1/50 - 1/100.

Alternative Names

COL4A1; collagen, type IV, alpha 1; collagen alpha-1(IV) chain; COL4A1 NC1 domain; collagen IV, alpha-1 polypeptide; collagen of basement membrane, alpha-1 chain; HANAC; POREN1; arresten;

Entrez Gene ID

Antigen Description

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen.Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Pathway

Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem;