Rabbit Anti-Human CNGA4 (a.a. 260-394) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat

Immunogen

Recombinant human CNGA4 protein; Source: E. coli derived, PET28a; Tag: 6*His; Domain: 260-394 aa of BC106936

Conjugate

Application Notes

WB: 1:500-1:2000

General Notes

This product (Catalog No. DPABH-08655) is a rabbit-derived polyclonal antibody raised against human CNGA4, targeting the amino acid region 260–394 of the protein. This antibody exhibits cross-reactivity with Human CNGA4 from mouse and rat. It has been affinity purified by Protein A. CNGA4 (cyclic nucleotide gated channel subunit alpha 4), also known as CNG4. It is expected to be located in cell membrane. Cyclic nucleotide-gated (CNG) channels are crucial for visual and olfactory transductions (PMID: 12432397). Native CNG channels are heterotetramers composed of homologous A and B subunits. Olfactory CNG channels are composed of three types of subunits, CNGA2, CNGA4, and CNGB1b (PMID: 15134638). CNGA4 is a modulatory subunit which contributes to the high cAMP sensitivity of the native olfactory channel. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation of native olfactory neurons to odorants (PMID: 11739959; 11739960). The molecular weight of CNGA4 is 65 kDa, and it can recognize the 48 kDa isoform.
DPABH-08655 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
DPABH-08655 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CNCA2; CNG5; CNGA4; CNGB2; OCNC2; OCNCb; OCNCBETA

Entrez Gene ID

UniProt ID