Anti-CLCN6 monoclonal antibody (DCABH-11032) Made to order

Rabbit anti-Human CLCN6 monoclonal antibody for WB, ELISA

View other CLCN6 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CLCN6 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CLCN6; chloride channel, voltage-sensitive 6; chloride channel 6; chloride transport protein 6; ClC 6; CLC 6
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLCN6 (Chloride Voltage-Gated Channel 6) is a Protein Coding gene. Diseases associated with CLCN6 include benign familial infantile epilepsy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Hepatic ABC Transporters. GO annotations related to this gene include ion channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLCN7. This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown.
Antigen Description
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB. Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene. 0The function about CLCN6 antigen include ATP binding; antiporter activity; ion channel activity; nucleotide binding; voltage-gated chloride channel activity; voltage-gated chloride channel activity.

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References


Tsubamoto, Y; Eto, K; et al. Hexamminecobalt(III) chloride inhibits glucose-induced insulin secretion at the exocytotic process. JOURNAL OF BIOLOGICAL CHEMISTRY 276:2979-2985(2001).
WU, CH; FROSTHOLM, A; et al. DIFFERENTIAL EXPRESSION OF GABA(A) BENZODIAZEPINE RECEPTOR SUBUNIT MESSENGER-RNAS AND LIGAND-BINDING SITES IN MOUSE CEREBELLAR NEURONS FOLLOWING IN-VIVO ETHANOL ADMINISTRATION - AN AUTORADIOGRAPHIC ANALYSIS. JOURNAL OF NEUROCHEMISTRY 65:1229-1239(1995).

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