Anti-CHMP4C (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to amino acids 1-233 of Human CHMP4C (NP_689497.1).

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

CHMP4C; charged multivesicular body protein 4C; Shax3; SNF7-3; VPS32C; charged multivesicular body protein 4c; hSnf7-3; vps32-3; hVps32-3; chromatin modifying protein 4C; chromatin-modifying protein 4c; SNF7 homolog associated with Alix 3; Snf7 homologue

Entrez Gene ID

UniProt ID

Antigen Description

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Pathway

Budding and maturation of HIV virion; ESCRT-III complex; Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT)