A synthetic peptide of human CHMP4C is used for rabbit immunization.
Conjugate
Unconjugated
Target
Alternative Names
CHMP4C; charged multivesicular body protein 4C; Shax3; SNF7-3; VPS32C; charged multivesicular body protein 4c; hSnf7-3; vps32-3; hVps32-3; chromatin modifying protein 4C; chromatin-modifying protein 4c; SNF7 homolog associated with Alix 3; Snf7 homologue
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Pathway
Budding and maturation of HIV virion; Disease; ESCRT-III complex; ESCRT-III complex; Endocytosis; Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); HIV Infection; HIV Life Cycle; Late Phase of HIV Life Cycle; Membrane Trafficking;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Carlton, JG; Caballe, A; et al. ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C. SCIENCE 336:220-225(2012).
Li, X; Li, XQ; et al. Engagement of new castle disease virus (NDV) matrix (M) protein with charged multivesicular body protein (CHMP) 4 facilitates viral replication. VIRUS RESEARCH 171:80-88(2013).
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COA
Certificate of Analysis