Anti-CHMP2B monoclonal antibody, clone FQS21918(C)

Name: Anti-CHMP2B monoclonal antibody, clone FQS21918(C)
SKU: DCABH-4833
Rating: 5 (1 reviews)

Rabbit anti-Human CHMP2B monoclonal antibody for WB, ICC/IF, IP, FC

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Clone

FQS21918(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to residues in Human CHMP2B (Uniprot: Q9UQN3)

Conjugate

Unconjugated

Applications

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/250 - 1/500; IP: 1/10 - 1/100; Flow Cyt: 1/10 - 1/100.

Target

Alternative Names

CHMP2B; charged multivesicular body protein 2B; chromatin modifying protein 2B; charged multivesicular body protein 2b; CHMP2.5; DKFZP564O123; VPS2 homolog B (S. cerevisiae); VPS2B; VPS2 homolog B; vacuolar protein-sorting-associated protein 2-2; DMT1; VP

Entrez Gene ID

25978

UniProt ID

B2RE76

Product Background

Antigen Description

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

Pathway

ESCRT-III complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; Membrane Trafficking, organism-specific biosystem.

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Documents

pdf COA

pdf SDS

pdf Datasheet

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References

Progranulin mutations in Dutch familial frontotemporal lobar degeneration

EUROPEAN JOURNAL OF HUMAN GENETICS

Authors: Bronner, Iraad F.; Rizzu, Patrizia; Seelaar, Harro; van Mil, Saskia E.; Anar, Burcu; Azmani, Asma; Kaat, Laura Donker; Rosso, Sonia; Heutink, Peter; van Swieten, John C.

Abstract

Mutations in the progranulin (PGRN) gene have recently been identified in frontotemporal lobar degeneration with ubiquitin inclusions linked to chromosome 17q21. We report here the finding of two novel frameshift mutations and three possible pathogenic missense mutations in the PGRN gene. Furthermore, we determined the frequency of PGRN mutations in familial cases recruited from a large population-based study of frontotemporal lobar degeneration carried out in The Netherlands.

Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis

NEUROBIOLOGY OF DISEASE

Authors: Hakkinen, Suvi; Chu, Stephanie A.; Lee, Suzee E.

Abstract

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong clinical, genetic and pathological overlap. This review focuses on the current understanding of structural, functional and molecular neuroimaging signatures of genetic FTD and ALS. We overview quantitative neuroimaging studies on the most common genes associated with FTD (MAPT, GRN), ALS (SOD1), and both (C9orf72), and summarize visual observations of images reported in the rarer genes (CHMP2B, TARDBP, FUS, OPTN, VCP, UBQLN2, SQSTM1, TREM2, CHCHD10, TBK1).