CELF4; CUGBP, Elav-like family member 4; Bruno (Drosophila) like 4, RNA binding protein , bruno like 4, RNA binding protein (Drosophila) , BRUNOL4; CUGBP Elav-like family member 4; CELF-4; bruno-like protein 4; RNA-binding protein BRUNOL4; RNA-binding p
BRUNOL4 is an RNA binding protein implicated in the regulation of pre mRNA alternative splicing. It mediates exon inclusion and/or exclusion in pre mRNA that are subject to tissue specific and developmentally regulated alternative splicing. It specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition; promotes exclusion of both the smooth muscle (SM) and non muscle (NM) exons in actinin pre mRNAs; binds to muscle specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre mRNA.
Pathway
mRNA processing, organism-specific biosystem.
Citations
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