Anti-NCAM1 monoclonal antibody, clone 844/NFN-299 [FITC + PE]

Clone

844/NFN-299

Species Reactivity

Human

Immunogen

The details of the immunogen for this antibody are not available.

Conjugate

Alternative Names

NCAM1; neural cell adhesion molecule 1; CD56; NCAM; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal 5.1H11; MSK39;

Entrez Gene ID

UniProt ID

Antigen Description

CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The antigen is present on 20-36% of normal peripheral blood lymphocytes (suppressor/cytotoxic T cells), on 60-85% of normal thymocytes and on a NK cells subset (CD3-CD8+). Patients with AIDS exhibit T cell lymphopenia, a loss of CD4+ lymphocytes and a relative increase in the CD8+ subtype and in the CD3+CD4-CD8-. CD56 is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. The CD56 antigen is present on NK cells and on a cytotoxic T lymphocytes subset that mediates non MHC restricted cytotoxicity. CD56 is also expressed by some myeloid leukaemia. Positive staining (tumors): myeloma, myeloid leukemia, neuroendocrine tumors, Wilm's tumor, adult neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, small cell lung carcinoma.

Pathway

Axon guidance, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Developmental Biology, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; Immune System, organism-specific biosystem;