Rabbit Anti-Human CCND3 (C-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues near the C terminal of human cyclin D3

Conjugate

Application Notes

IHC: 1:50-1:200

General Notes

This product (Catalog No. DPABH-14168) is a rabbit-derived IgG polyclonal antibody raised against human CCND3. It has been affinity purified by protein A. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
DPABH-14168 is suitable for use in IHC (1:50–1:200) application.
DPABH-14168 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CCND3; cyclin D3; D3-type cyclin; G1/S-specific cyclin D3; G1/S-specific cyclin-D3

Entrez Gene ID

UniProt ID