Anti-CCND3 monoclonal antibody, clone TQN352

Antibody Isotype

IgG1

Clone

TQN352

Species Reactivity

Human

Immunogen

Recombinant full length protein (Human)

Conjugate

Alternative Names

CCND3; cyclin D3; G1/S-specific cyclin-D3; D3-type cyclin; G1/S-specific cyclin D3;

Entrez Gene ID

UniProt ID

Antigen Description

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Pathway

B Cell Receptor Signaling Pathway, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem;