Anti-CBX4 monoclonal antibody, clone FQS23399

Antibody Isotype

IgG

Clone

FQS23399

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CBX4 aa 500 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: O00257

Conjugate

Application Notes

WB: 1/10000 - 1/50000.

Alternative Names

CBX4; chromobox homolog 4; chromobox homolog 4 (Drosophila Pc class); E3 SUMO-protein ligase CBX4; hPC2; NBP16; NS5ATP1 binding protein 16; Pc class 2 homolog (Drosophila); PC2; Pc class 2 homolog; polycomb 2 homolog; NS5ATP1-binding protein 16; chromobox

Entrez Gene ID

UniProt ID

Antigen Description

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Pathway

C-MYB transcription factor network, organism-specific biosystem; Regulation of retinoblastoma protein, organism-specific biosystem;