Anti-CBX3 (aa 74-123) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide: EAFLNSQKAG KEKDGTKRKS LSDSESDDSK SKKKRDAADK PRGFARGLDP, corresponding to a region within internal sequence amino acids 74-123 of Human HP1 gamma

Conjugate

Application Notes

WB: 1.25 μg/ml; IHC-P: 4 - 8 μg/ml; ICC/IF: 1 μg/ml;

Alternative Names

CBX3; chromobox homolog 3; HECH; HP1-GAMMA; HP1Hs-gamma; chromobox protein homolog 3; HP1 gamma homolog; modifier 2 protein; heterochromatin-like protein 1; heterochromatin protein HP1 gamma; heterochromatin protein 1 homolog gamma; chromobox homolog 3 (H

Entrez Gene ID

UniProt ID

Antigen Description

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Pathway

Diurnally regulated genes with circadian orthologs; RNA Polymerase I Chain Elongation; RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription;