Rabbit Anti-Human CBX3 (N-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthetic peptide corresponding to residues near the N terminal of human chromobox homolog 3

Conjugate

Application Notes

WB: 1:500-1:2000
IHC: 1:50-1:200

General Notes

This product (Catalog No. DPABH-00476) is a rabbit-derived IgG polyclonal antibody raised against human CBX3. This antibody exhibits cross-reactivity with CBX3 from mouse. It has been affinity purified by protein A. At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
DPABH-00476 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:50–1:200) applications.
DPABH-00476 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

HECH; HP1-GAMMA; HP1Hs-gamma

Entrez Gene ID

UniProt ID