Anti-CASR monoclonal antibody, clone IM2500

Antibody Isotype

IgG1

Clone

IM2500

Species Reactivity

Mouse; Rat; Rabbit; Human

Immunogen

Synthetic peptide within Human Calcium Sensing Receptor (N terminal). The exact sequence is proprietary. (Extracellular region).Database link: P41180

Conjugate

Application Notes

WB: 1/50 - 1/200; IP: 5 - 10 μg/ml; IHC-P: 1/50 - 1/200; IHC-Fr: 1/50 - 1/200; ICC/IF: 1/50 - 1/200

Alternative Names

CASR; calcium-sensing receptor; HHC, HHC1, hypocalciuric hypercalcemia 1; extracellular calcium-sensing receptor; FHH; GPRC2A; NSHPT; severe neonatal hyperparathyroidism; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor; C

Entrez Gene ID

UniProt ID

Antigen Description

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Pathway

Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; E-cadherin signaling in keratinocytes, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem;