Synthetic peptide corresponding to internal residues of human CASP4
Conjugate
Unconjugated
Applications
Application Notes
IHC: 1:30-150
General Notes
This product (Catalog No. DPABH-28484) is a rabbit-derived polyclonal antibody raised against human CASP4. It has been affinity purified by Protein A. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. DPABH-28484 is suitable for use in IHC (1:30–1:150) application. DPABH-28484 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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