Specifications
Immunogen
Synthetic peptide corresponding to Human Caspase-10 (C terminal).
Applications
Application Notes
WB: 1/500 - 1/1000; IHC-P: 5 μg/ml; ICC/IF: 1/100 - 1/500;
Target
Alternative Names
CASP10; caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine proteas
Product Background
Antigen Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp--AMC and Asp-Glu-Val-Asp--AMC.Isoform C is proteolytically inactive.
Pathway
Apoptosis; Apoptosis; Apoptosis Modulation and Signaling; Death Receptor Signalling
Citations
Publication ()
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COA
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