Anti-CARS monoclonal antibody (DCABH-10836) Made to order

Rabbit anti-Human CARS monoclonal antibody for WB, ELISA

View other CARS antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CARS is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CARS; cysteinyl-tRNA synthetase; cysteine--tRNA ligase, cytoplasmic; CARS1; cysteine tRNA ligase 1; cytoplasmic
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CARS (Cysteinyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with CARS include inflammatory myofibroblastic tumor and hypocalcemia, autosomal dominant. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include protein homodimerization activity and tRNA binding. An important paralog of this gene is CARS2. This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.
Antigen Description
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Note=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK. The function about CARS antigen include ATP binding; ATP binding; cysteine-tRNA ligase activity; cysteine-tRNA ligase activity; cysteine-tRNA ligase activity; ligase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein homodimerization act.
Pathway
Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Oren, R; Hod-Marco, M; et al. Functional Comparison of Engineered T Cells Carrying a Native TCR versus TCR-like Antibody-Based Chimeric Antigen Receptors Indicates Affinity/Avidity Thresholds. JOURNAL OF IMMUNOLOGY 193:5733-5743(2014).
McNally, RJQ; James, PW; et al. No Rise in Incidence but Geographical Heterogeneity in the Occurrence of Primary Biliary Cirrhosis in North East England. AMERICAN JOURNAL OF EPIDEMIOLOGY 179:492-498(2014).

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