Anti-CARD11 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.

Conjugate

Alternative Names

CARD11; caspase recruitment domain family, member 11; PPBL; BENTA; BIMP3; IMD11; CARMA1; caspase recruitment domain-containing protein 11; carma 1; CARD-containing MAGUK protein 1; bcl10-interacting maguk protein 3

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

Pathway

Activation of NF-kappaB in B cells; Adaptive Immune System; B Cell Receptor Signaling Pathway; B cell receptor signaling pathway; BCR signaling pathway; Downstream TCR signaling; Downstream signaling events of B Cell Receptor (BCR); FCERI mediated NF-kB activation