Anti-CARD11 (aa 481-580) polyclonal antibody

Species Reactivity

Human

Immunogen

CARD11 (NP_115791, 481 a.a. ~ 580 a.a) partial recombinant protein with GST tag. The sequence is KYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNS FTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTV

Conjugate

Alternative Names

CARD11; caspase recruitment domain family, member 11; PPBL; BENTA; BIMP3; IMD11; CARMA1; caspase recruitment domain-containing protein 11; carma 1; CARD-containing MAGUK protein 1; bcl10-interacting maguk protein 3;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Pathway

Activation of NF-kappaB in B cells; B Cell Receptor Signaling Pathway; BCR signaling pathway; Downstream signaling events of B Cell Receptor (BCR).