General Notes
This product (Catalog No. DPABH-00784) is a rabbit-derived polyclonal antibody raised against human CAMK2B. This antibody exhibits cross-reactivity with Human CAMK2B from mouse and rat. It has been affinity purified by Protein A. CaMKII beta (Calcium/calmodulin-dependent protein kinase type II subunit beta ), also named as CAMK2B, CAM2 or CAMKB, belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and CaMK subfamily. It is a member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. It plays a distinct role in the induction of anergy in T lymphocytes, by differential regulation of IL10 and IL2 gene transcription suggesting MEF2A as a molecular target which can integrate different calcium signals (PMID:22578382). CAMK2B has 8 isoforms produced by alternative splicing with the molecular weight 50-73 kDa.
DPABH-00784 is suitable for use in Western blot (WB) (1:1,000–1:6,000), IHC (1:20–1:200), IF/ICC (1:20–1:200) applications.
DPABH-00784 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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