Anti-CALR monoclonal antibody, clone 2H7B8

Antibody Isotype

IgG2a

Clone

2H7B8

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide: EEEDVPGQAKDELC conjugated to KLH, corresponding to amino acids 405-417 of Human Calreticulin.

Conjugate

Application Notes

WB: 1/500 - 1/2000; ELISA: 1/10000; IHC-P: 1/200 - 1/1000; ICC/IF: 1/200 - 1/1000;

Alternative Names

CALR; calreticulin; autoantigen Ro; cC1qR; CRT; FLJ26680; RO; Sicca syndrome antigen A (autoantigen Ro; calreticulin); SSA; CRP55; ERp60; HACBP; grp60; calregulin; endoplasmic reticulum resident protein 60; Sicca syndrome antigen A (autoantigen Ro; calret

Entrez Gene ID

UniProt ID

Antigen Description

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.

Pathway

Activation of Chaperone Genes by ATF6-alpha, organism-specific biosystem; Activation of Chaperones by ATF6-alpha, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem;