Anti-CACNB1 monoclonal antibody, clone T8-29

Antibody Isotype

IgG2a

Clone

T8-29

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide: PMEVFDPSPQGKYSKR, corresponding to amino acids 19-34 of Rat CACNB1 (NP_059042).

Conjugate

Application Notes

WB: 1 - 10 μg/ml; ICC/IF: 1 - 10 μg/ml; IHC-Fr: 0.1 - 1 μg/ml; IHC-P: 0.1 - 1 μg/ml;

Alternative Names

CACNB1; calcium channel, voltage-dependent, beta 1 subunit; voltage-dependent L-type calcium channel subunit beta-1; CAB1; calcium channel beta 1 subunit; brain calcium channel beta 1 subunit; calcium channel voltage-dependent subunit beta 1;

Entrez Gene ID

UniProt ID

Antigen Description

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem;