Anti-CACNA2D1 (internal region) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to internal region of human CACNA2D1. The sequence is C-QEIFNKYNKDKKVR

Conjugate

Application Notes

ELISA: 1:16000; WB: 0.03-0.1 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

CACNA2D1; calcium channel, voltage-dependent, alpha 2/delta subunit 1; CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3; voltage-dependent calcium channel subunit alpha-2/delta-1; long intergenic non-protein coding RNA 1112; calcium channel, L type, alpha 2

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Pathway

Adrenergic signaling in cardiomyocytes; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels; Hypertrophic cardiomyopathy (HCM)