Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3-5 end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Schilders, G; Egberts, WV; et al. C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome. ARTHRITIS AND RHEUMATISM 56:2449-2454(2007).
CLAESSON, MH; ENDEL, B; et al. ANTIBODIES DIRECTED AGAINST MONOMORPHIC AND EVOLUTIONARY CONSERVED SELF EPITOPES MAY BE GENERATED IN KNOCK-OUT MICE - DEVELOPMENT OF MONOCLONAL-ANTIBODIES DIRECTED AGAINST MONOMORPHIC MHC CLASS-I DETERMINANTS. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 40:257-264(1994).
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COA
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