General Notes
This product (Catalog No. DPABH-24061) is a rabbit-derived polyclonal antibody raised against human BPNT1, targeting the amino acid region 1–308 of the protein. It has been affinity purified by Protein A. In mammals, the enzyme 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1), a cytoplasmic 3'-nucleotidase, catalyzes the hydrolysis of PAPS to adenosine 5'-phosphosulfate (APS) and inorganic phosphate (Pi). This reaction reverses the final step of PAPS biosynthesis and is essential for sulfur homeostasis, with BPNT1 exhibiting specificity for the 3'-phosphate group on PAPS. Homologous enzymes in other organisms, such as CysQ in bacteria and SAL1 in plants, perform analogous functions, often with broader substrate specificity toward both PAPS and related nucleotides. In some species, nonspecific phosphatases contribute to this breakdown, ensuring efficient turnover under varying physiological conditions.
DPABH-24061 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-24061 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Alternative Names
3'(2'),5'-bisphosphate nucleotidase 1; 3.1.3.7; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; Bisphosphate 3'-nucleotidase 1; BPntase 1; HsPIP; Inositol-polyphosphate 1-phosphatase; 3.1.3.57; BPNT1
COA
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