Recombinant full length protein corresponding to Human BMPR1B aa 1-502.Sequence: MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTD GYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERN ECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRY KRQETRPRYSIGLEQDETYIP
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/50 - 1/200; WB: 1/500 - 1/2000.
Target
Alternative Names
BMPR1B; bone morphogenetic protein receptor, type IB; bone morphogenetic protein receptor type-1B; ALK6; CDw293; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase; ALK-6;
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.
Pathway
Cytokine-cytokine receptor interaction; Ovarian Infertility Genes; Signal Transduction; Signaling by BMP; TGF-beta signaling pathway;
Citations
Publication ()
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