General Notes
This product (Catalog No. DPABH-21473) is a rabbit-derived polyclonal antibody raised against human BIN1, targeting the amino acid region 1–439 of the protein. This antibody exhibits cross-reactivity with Human BIN1 from mouse and rat. It has been affinity purified by Protein A. BIN1 (Bridging integrator 1), also known as amphiphysin II or Myc box-dependent-interacting protein 1, is a ubiquitous nucleocytoplasmic adaptor protein that was identified initially as an MYC-interacting proapoptotic tumor suppressor. Alternative splicing of the gene results in multiple transcript variants encoding different isoforms. BIN1 is a key regulator of different cellular functions, including endocytosis and membrane recycling, cytoskeleton regulation, DNA repair, cell cycle progression, and apoptosis (PMID: 24590001).
DPABH-21473 is suitable for use in Western blot (WB) (1:1,000–1:6,000), IHC (1:50–1:500), IF-P (1:50–1:500) applications.
DPABH-21473 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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